Prestonsburg took the lead away from Lewis County late in the third quarter and added a fourth-quarter score to earn a 42-28 win over the Lions at Josh Francis Memorial Field on Friday night.
The Blackcats rushed for six touchdowns while improving to 3-1.
Running back Jacob Rose ran 29 times for 196 yards and three touchdowns. Dalton Elliott added 76 yards and a pair of scores. Colin Hatfield rushed for a touchdown.
Placekicker Bryan Amador booted a field goal and three extra points.
The Blackcats will travel down US 23 to take on Betsy Layne (4-0) on Friday night. Kickoff is 7:30 pm.